Journal
NPJ DIGITAL MEDICINE
Volume 3, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41746-020-0247-1
Keywords
-
Funding
- National Medical Research Council Singapore, Ministry of Health, Singapore
- Tanoto Foundation
- National Medical Research Council (NMRC), Ministry of Health (MOH), Singapore (National Health Innovation Center, Innovation to Develop Grant) [NHIC-I2D-1409022]
- Health Service Research Grant
- SingHealth Foundation Research Grant [SHF/FG648S/2015]
- NMRC, MOH [0796/2003, IRG07nov013, IRG09nov014, STaR/0003/2008, STaR/2013, CG/SERI/2010]
- Biomedical Research Council [08/1/35/19/550, 09/1/35/19/616]
- MOH, Singapore [AIC/RPDD/ SIDRP/SERI/FY2013/0018, AIC/HPD/FY2016/0912]
Ask authors/readers for more resources
Deep learning (DL) has been shown to be effective in developing diabetic retinopathy (DR) algorithms, possibly tackling financial and manpower challenges hindering implementation of DR screening. However, our systematic review of the literature reveals few studies studied the impact of different factors on these DL algorithms, that are important for clinical deployment in real-world settings. Using 455,491 retinal images, we evaluated two technical and three image-related factors in detection of referable DR. For technical factors, the performances of four DL models (VGGNet, ResNet, DenseNet, Ensemble) and two computational frameworks (Caffe, TensorFlow) were evaluated while for image-related factors, we evaluated image compression levels (reducing image size, 350, 300, 250, 200, 150 KB), number of fields (7-field, 2-field, 1-field) and media clarity (pseudophakic vs phakic). In detection of referable DR, four DL models showed comparable diagnostic performance (AUC 0.936-0.944). To develop the VGGNet model, two computational frameworks had similar AUC (0.936). The DL performance dropped when image size decreased below 250 KB (AUC 0.936, 0.900, p < 0.001). The DL performance performed better when there were increased number of fields (dataset 1: 2-field vs 1-field-AUC 0.936 vs 0.908, p < 0.001; dataset 2: 7-field vs 2-field vs 1-field, AUC 0.949 vs 0.911 vs 0.895). DL performed better in the pseudophakic than phakic eyes (AUC 0.918 vs 0.833, p < 0.001). Various image-related factors play more significant roles than technical factors in determining the diagnostic performance, suggesting the importance of having robust training and testing datasets for DL training and deployment in the real-world settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available