4.7 Article

Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 17, Pages 2630-2633

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00394h

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Funding

  1. National Natural Science Foundation of China [21672135, 21975149, 21402115, 51403122]
  2. Natural Science Foundation of Shaanxi Province [2018JM5086]
  3. Fundamental Research Funds for the Central Universities [GK201902006]
  4. Funded Projects for the Academic Leaders and Academic Backbones, Shaanxi Normal University [18QNGG007]

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Two efficient photosensitizers (PSs) with aggregation-induced emission characteristics were designed and synthesized for specific lysosome-targeted photodynamic therapy (PDT). Both PSs efficiently discriminated Gram-positive bacteria from Gram-negative bacteria and killed Gram-positive bacteria through the PDT effect.

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