Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 22, Issue 7, Pages 4158-4164Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cp06321h
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Funding
- Agence Nationale pour la Recherche [ANR G4-TopiPro ANR-16-CE11-0006-01]
- CBH-EUR-GS [ANR-17-EURE-0003]
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Surface plasmon resonance (SPR) was used to investigate the interaction between N-methyl mesoporphyrin IX (NMM) and different G-quadruplex (G4) topologies. The study was associated with circular dichroism analysis (CD) to assess the topology of the G4s when they interacted with NMM. We demonstrate the high selectivity of NMM for the parallel G4 structure with a dissociation constant at least ten times lower than those of other G4 topologies. We also confirm the ability of NMM to shift the G4 conformation from both the hybrid and antiparallel topologies toward the parallel structure.
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