Journal
JOURNAL OF CANCER
Volume 11, Issue 9, Pages 2572-2579Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.37959
Keywords
PDAC; PVT1; miR-519d-3p; HIF-1A
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Funding
- Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province [CXPJJ H11800001-2018329]
- Health commission of Hubei Province scientific research project [WJ2019H133]
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The long, noncoding RNA (lncRNA) PVT1, as an important epigenetic regulator, has a critical role in carcinogenesis. However, its role in pancreatic ductal adenocarcinoma (PDAC) has not been fully investigated. Here, the up-regulated expression of lncRNA PVT1 is found in our PDAC tumor samples. Knockdown of it suppressed PDCA cells growth and glycolysis. An inverse association between miR-519d-3p and PVT1 was found. RIP, RNA pulldown and luciferase assay showed that PVT1 directly targets miR-519d-3p by binding with microRNA binding site. Bioinformatics analysis and study indicated that HIF-1A is a target of miR-519d-3p. Collectively, our findings suggested that PVT1 could act as an oncogenic lncRNA, and promote tumor progression by regulating HIF-1A via competing with miR-519d-3p.
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