Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 16, Issue 8, Pages 1474-1480Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.39958
Keywords
WT1; breast neoplasms; prognosis; carcinogenesis
Categories
Funding
- National Natural Science Foundation of China [81102030]
- Biotechnology Innovation Program of Southwest Hospital [SWH2016JCYB-39]
- Talents Training Program of Third Military Medical University [2017MPRC-18]
- Chongqing Basic Research and Frontier Exploration Project [cstc2018jcyj A0137]
- Military Medical Staff Innovation Plan of Southwest Hospital [SWH2018BJLC-04]
- Army Medical University [XZ-2019-505-042]
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Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.
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