Journal
CLINICAL CASE REPORTS
Volume 8, Issue 5, Pages 911-918Publisher
WILEY
DOI: 10.1002/ccr3.2769
Keywords
asfotase alfa; dental signs; enzyme replacement therapy; hypophosphatasia; premature loss of primary teeth
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Funding
- Alexion LLC, Moscow, Russia
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The most frequent dental signs of hypophosphatasia in children are premature loss of primary teeth, decrease in height of alveolar bone, and malocclusions. Enzyme replacement therapy with Asfotase alfa might be associated with stabilization of dental status.
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