Journal
CHEMICAL SCIENCE
Volume 11, Issue 9, Pages 2369-2374Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc06310b
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Funding
- NSFC [51473028]
- Key Scienti.c and Technological Project of Jilin Province [20160307016GX, 20190701010GH]
- Development and Reform Commission of Jilin Province [20160058]
- Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
- EPSRC [EL/L02621X/1]
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Developing multifunctional photosensitizers (PSs) is needed to effectively simplify cancer treatment, but it remains a big challenge. Here, two red-emitting AIE-active, donor-acceptor (D-A) PSs with small Delta E-ST and their AIE nanoparticles, are rationally designed and synthesized. The PS1 NPs exhibit bright red-emission with high quantum yield, appropriate O-1(2) generation ability and good biocompatibility. More importantly, PS1 NPs can strongly light up the cytoplasm by gently shaking the cells for only 5 s at room temperature, indicating ultrafast staining and mild incubation conditions. In vitro and in vivo cell tracing demonstrate that PS1 NPs can track cells over 14 days, and effectively inhibit tumor growth upon irradiation. To the best of our knowledge, this work is the first example of a PS that integrates image-guided PDT, ultrafast staining and long-term tracing functions, demonstrating the all-in-one concept which offers great advantages for potential clinical applications.
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