Journal
JOURNAL OF BONE AND MINERAL METABOLISM
Volume 36, Issue 1, Pages 1-11Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00774-017-0860-5
Keywords
Extracellular vesicles; Exosomes; Osteoblasts; Osteoclasts; Bone metastasis
Funding
- National Natural Science Foundation of China (NSFC) [81502465]
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Extracellular vesicles (EVs) are phospholipid membrane-enclosed entities containing specific proteins, RNA, miRNA, and lncRNA. EVs are released by various cells and play a vital role in cell communication by transferring their contents from the host cells to the recipient cells. The role of EVs has been characterized in a wide range of physiological and pathophysiological processes. In this context, we highlight recent advances in our understanding of the regulatory effects of EVs, with a focus on bone metabolism and the bone microenvironment. The roles of EVs in cell communication among bone-related cells, stem cells, tumor cells, and other cells under physiological or pathological conditions are also discussed. In addition, promising applications for EVs in treating bone-related diseases are proposed.
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