Journal
THERANOSTICS
Volume 10, Issue 9, Pages 4150-4167Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.42735
Keywords
F-box; E3 ligase; ubiquitin; substrate; cancer progression
Categories
Funding
- National Natural Science Foundation of China [81672440, 31701156, 81972625]
- Innovation program of science and research from the DICP, CAS [DICP TMSR201601, DICP ZZBS201803]
- Department of Liaoning Science and Technology [1564992449013, 2019020176-JH1/103-02]
- Central financial fund for promoting medical service and safeguarding capability (Capability construction of medical and health organizations)
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E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains. According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO). Here, we summarize the substrates of F-box proteins, discuss the important molecular mechanism and emerging role of F-box proteins especially from the perspective of cancer development and progression. These findings will shed new light on malignant tumor progression mechanisms, and suggest the potential role of F-box proteins as cancer biomarkers and therapeutic targets for future cancer treatment.
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