Journal
JOURNAL OF BIOTECHNOLOGY
Volume 256, Issue -, Pages 21-26Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2017.07.009
Keywords
Co-culture fermentation; Lactococcus lactis subsp lactis; Lactate consumption; Molasses based medium; Nisin; Yarrowia lipolytica
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Funding
- Science and Technology Park, University of Tehran [94006]
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Nisin is a safe, approved and commercial bacteriocin that is produced by Lactococcus lactis subsp. lactis. Since lactate accumulation in fermentation medium reduces L. lactis growth and nisin production, Yarrowia lipolytica, a lactate consuming yeast and L. lactis subsp. lactis, were simultaneously cultured in a molasses based medium. Y. lipolytica is not able to consume sucrose as carbon source, but rather consumes lactate and hence decrease lactic acid titer by 10% in the medium. Lactic acid consumption, 15% increased pH value and stimulated L. lactis growth. In the mixed culture, nisin production and L. lactis growth were 50% and 49% higher than that of pure culture, respectively. Also the results showed that specific growth rate of L. lactis increased 4 times more than that of the pure culture.
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