Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 7, Issue 5, Pages 796-809Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo00001a
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Funding
- National Natural Science Foundation of China [21971176, 21572150]
- Program for New Century Excellent Talents in University [NCET-12-0743]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A bifunctional organocatalyst catalyzed tandem annulation reaction between beta,gamma-unsaturated alpha-ketoesters with alpha-arylidene pyrazolinones was reported. The tandem Michael-aldol process allows access to optically active bi-spirocyclic pyrazolone and oxindole compounds in high yields with good to excellent enantioselectivity and diastereoselectivity. The resulting bi-spirocyclic compounds possess highly dense functionalized substituents, two all-carbon spiro quaternary stereocenters and one hemiketal stereogenic centers.
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