4.7 Article

Fluorescent nanosensor for in situ detection of phosphate and alkaline phosphatase in mice with parathyroid dysfunction

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 16, Pages 2431-2434

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08828h

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Funding

  1. National Natural Science Foundation of China [21535004, 91753111, 21874084]
  2. Natural Science Foundation of Shandong Province [ZR2019JQ07]
  3. Key Research and Development Program of Shandong Province [2018YFJH0502]

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A composite nanosensor based on Zr(iv)-MOFs and PNPP was developed, and was successfully applied for the in situ fluorescence imaging of phosphate and ALP levels in mice with parathyroid dysfunction. The current work provides new ideas for further development of the diagnosis of parathyroid diseases.

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