Journal
JOURNAL OF BIOPHOTONICS
Volume 10, Issue 8, Pages 990-996Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201600317
Keywords
spatially offset Raman spectroscopy; bone; osteogenesis imperfecta
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Funding
- National Institutes of Health [R01 AR070613, R21 AR061285]
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The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements. [GRAPHICS] .
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