Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 22, Issue 8, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.22.8.085003
Keywords
fluorescence spectroscopy; metabolism; advanced glycation end products; mitochondrial function; laser Doppler flowmetry; diabetes mellitus; diagnostic volume
Funding
- European Union's Horizon research and innovation programme [703145]
- Academy of Finland [296408, 290596]
- President of the Russian Federation [MK-7168.2016.8]
- Marie Curie Actions (MSCA) [703145] Funding Source: Marie Curie Actions (MSCA)
- Academy of Finland (AKA) [296408, 296408] Funding Source: Academy of Finland (AKA)
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According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
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