4.5 Article

Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins

Journal

JOURNAL OF BIOMEDICAL OPTICS
Volume 22, Issue 2, Pages -

Publisher

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.22.2.026007

Keywords

optics; photonics; diffuse optical spectroscopy; medical instrumentation; clinical applications; light propagation in tissue

Funding

  1. National Institutes of Health (NIH) [R01EB011574-01A1]
  2. NIH
  3. National Science Foundation graduate research fellowship program
  4. Department of Defense [W81XWH-09-1-0410]
  5. Small Business Technology Transfer Phase II [2R42CA128160-02]
  6. Fast Spectral Imaging Device for Tumor Margin Mapping awarded to Zenalux, Inc
  7. Duke University

Ask authors/readers for more resources

We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 x 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [mu'(s)(lambda) and mu(a)(lambda)] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x, y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 x 2 cm(2) area in similar to 9 min. The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast. (C) 2017 Society of Photo-Optical Instrumentation Engineers

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available