Journal
DALTON TRANSACTIONS
Volume 44, Issue 8, Pages 3701-3707Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt03631j
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Funding
- Agence Nationale pour la Recherche, Kinetelodrugs [ANR 07-BLAN-0343-01]
- Quarpdiem [ANR-12-BSV8-0008]
- Region Midi-Pyrenees
- Labex Arcane [ANR-11-LABX-0003-01]
- National Core facility Program for Biotechnology in Taiwan
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G-quadruplex DNA ligands attract much attention because of their potential use in biology. Indeed they may interfere with G-quadrulex nucleic acid function in cells. Most of the G-quadruplex ligands so far reported (including also metal complexes) are large planar aromatic compounds that interact by pi-pi stacking with an external G-quartet of quadruplex. Porphyrins are well-known G-quadruplex ligands. We report herein a new porphyrin scaffold (meso-tetrakis(4-(N-methyl-pyridinium-2-yl) phenyl) porphyrin) able to strongly and selectively bind to G-quadruplex DNA. We show that even when this porphyrin is metallated with cobalt(III), i.e. it carries two water molecules as axial ligands on the cobalt ion, on each face of the porphyrin, the interaction occurs by a pi-stacking-like mode with an external G-quartet of quadruplex DNA.
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