Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 106, Issue 1, Pages 160-167Publisher
WILEY
DOI: 10.1002/jbm.a.36220
Keywords
In-vitro fretting corrosion; cell-biomaterial interaction; orthopedic alloys; wear and corrosion; electrochemistry effects on cells
Funding
- Stryker Orthopedics
- Depuy Synthes
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Fretting corrosion (or mechanically assisted corrosion, MAC) is a major corrosion mechanism in modular orthopedic implants. There is a complex interplay between fretting corrosion and the surrounding biological environment that includes particle generation and electrochemical potential excursions and currents. The goal of this work is to directly investigate the effects of fretting on cells in vitro. Using an in vitro fretting device, MC3T3 preosteoblasts were cultured onto Ti-6Al-4V disks adjacent to the fretting site. Under fretting corrosion conditions, cell viability dramatically decreased to 0.5% with the voltage drop reaching 21 V (vs. Ag/AgCl). Under the same fretting corrosion conditions, but potentiostatically holding the Ti-6Al-4V sample surface potential to 2300 mV or 250 mV (vs. Ag/AgCl), the cell viability increases to 70% and 38%, respectively. The results indicate that both cathodic potential excursions and wear debris play significant roles in affecting cell viability. (C) 2017 Wiley Periodicals, Inc.
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