Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 27, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12929-020-00647-w
Keywords
Long noncoding RNA; Cardiovascular; Disease; Development
Categories
Funding
- Taiwan Ministry of Science Technology [103-2320-B-002-068-MY2, 105-2628-B-002 -042-MY4, 108-2314-B-002-199MY3]
- Taiwan National Health Research Institute [NHRI-EX104-10418SC, NHRI-EX109]
- CRC Translational Research Grant from the Institute of Biomedical Sciences at Academia Sinica, Taiwan [IBMS-CRC108-P03]
- National Taiwan University Hospital [NTUH.109-T15, 106-P02, 105-CGN01, UN106-026, 106-N3740, VN106-12, 107-T02, UN107-019, 107-N4062, VN10703, 108-T16, VN108-06, NTUH.108-P04, 108-N4198, 108-S4247, 108-EDN03]
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With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous group of non-coding transcripts longer than 200 nucleotides. Emerging evidence suggests that lncRNAs are functional and contribute to the complex regulatory networks involved in cardiovascular development and diseases. In this article, we will review recent evidence on the roles of lncRNAs in the biological processes of cardiovascular development and disorders. The potential applications of lncRNAs as biomarkers and targets for therapeutics are also discussed.
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