Journal
JOURNAL OF BIOMECHANICS
Volume 50, Issue -, Pages 20-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2016.11.016
Keywords
Mechanotransduction; Platelet activation; Mechanical circulatory support; Thrombosis; Fluid shear stress
Categories
Funding
- National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health [5U01EB012487-05]
Ask authors/readers for more resources
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for free flow activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available