Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 28, Issue 18, Pages 2186-2195Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2017.1388556
Keywords
Acute kidney injury; co-gels; collagen; decellularized vascular matrix; mesenchymal stem cells; paracrine secretion
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Transplantation of mesenchymal stem cells (MSCs) is promising for treatment of acute kidney injury (AKI), but their therapeutic effects are often limited under normal conditions. In this study, we prepared the co-gels of decellularized vascular matrix and collagen, and investigated whether the co-gels increase the therapeutic potentials of MSCs on AKI. In vitro studies indicated that the co-gels enhanced the paracrine effects of MSCs, and significantly reduced the apoptosis of MSCs under oxidative environments. When the co-gels were cotransplanted with MSCs into the kidney of model rats with ischemiareperfusion (I/R)-induced AKI, the survival and paracrine effects of MSCs were enhanced in the injured kidney. More importantly, the co-gels increased the therapeutic effects of MSCs for AKI, as indicated by cell apoptosis, tissue damage, vascularization and renal function. Therefore, the co-gels of decellularized vascular matrix and collagen improved the therapeutic effects of MSCs, and might be promising for AKI treatment.
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