Journal
JOURNAL OF BIOLOGICAL PHYSICS
Volume 43, Issue 4, Pages 471-479Publisher
SPRINGER
DOI: 10.1007/s10867-017-9463-6
Keywords
Cell mechanics; Malaria; Merozoite; Erythrocyte; Contact mechanics; Parasite invasion
Categories
Funding
- National Research Foundation of South Africa [UID 92531, 93542]
- South African Medical Research Council [SIR 328148]
Ask authors/readers for more resources
In this study, we used a continuum model based on contact mechanics to understand the mechanics of merozoite invasion into human erythrocytes. This model allows us to evaluate the indentation force and work as well as the contact pressure between the merozoite and erythrocyte for an early stage of invasion (gamma = 10%). The model predicted an indentation force of 1.3e N-11 and an indentation work of 1e (-18)J. The present analytical model can be considered as a useful tool not only for investigations in mechanobiology and biomechanics but also to explore novel therapeutic targets for malaria and other parasite infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available