Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 22, Issue 2-3, Pages 339-365Publisher
SPRINGER
DOI: 10.1007/s00775-016-1431-2
Keywords
Nonheme iron enzymes; 2-His-1-carboxylate facial triad; O-2 activation; alpha-Ketoglutarate-dependent enzymes; Halogenases; Pterin-dependent hydroxylases; Rieske oxygenases
Funding
- U.S. National Science Foundation [CHE-1361773]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1361773] Funding Source: National Science Foundation
Ask authors/readers for more resources
The 2-His-1-carboxylate facial triad is a widely used scaffold to bind the iron center in mononuclear nonheme iron enzymes for activating dioxygen in a variety of oxidative transformations of metabolic significance. Since the 1990s, over a hundred different iron enzymes have been identified to use this platform. This structural motif consists of two histidines and the side chain carboxylate of an aspartate or a glutamate arranged in a facial array that binds iron(II) at the active site. This triad occupies one face of an iron-centered octahedron and makes the opposite face available for the coordination of O-2 and, in many cases, substrate, allowing the tailoring of the iron-dioxygen chemistry to carry out a plethora of diverse reactions. Activated dioxygen-derived species involved in the enzyme mechanisms include iron(III)-superoxo, iron(III)-peroxo, and high-valent iron(IV)-oxo intermediates. In this article, we highlight the major crystallographic, spectroscopic, and mechanistic advances of the past 20 years that have significantly enhanced our understanding of the mechanisms of O-2 activation and the key roles played by iron-based oxidants.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available