Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 41, Pages 16804-16809Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.789271
Keywords
Complex I; hydrogen peroxide; mitochondria; reactive oxygen species (ROS); superoxide ion; complex III
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Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity are known to leak electrons to oxygen to produce O-2(center dot-). and/or H2O2. We discuss their contributions to O-2(center dot-)./H2O2 production under native conditions in mitochondria oxidizing different substrates and in conditions mimicking physical exercise and the changes in their capacities after caloric restriction. We review the use of S1QELs and S3QELs, suppressors of mitochondrial O-2(center dot-)./H2O2 generation that do not inhibit oxidative phosphorylation, as tools to characterize the contributions of specific sites in situ and in vivo.
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