Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 31, Pages 12727-12734Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.781823
Keywords
erythropoiesis; hepatocyte; infection; inflammation; iron metabolism
Categories
Funding
- National Institutes of Health [T32 HL072752, R01DK065029]
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The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels. Hepcidin, the master regulator of iron homeostasis, controls iron flows into plasma through inhibition of the only known mammalian cellular iron exporter ferroportin. Hepcidin is feedback-regulated by iron status and strongly modulated by inflammation and erythropoietic demand. This review highlights recent advances that have changed our understanding of iron metabolism and its regulation.
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