Journal
RSC ADVANCES
Volume 10, Issue 13, Pages 7708-7717Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra09385k
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Funding
- National Natural Science Foundation of China [31771081, 81171727]
- Science and Technology Commission of Shanghai Municipality [18ZR1445100, 19441901900, 19ZR1439700]
- S&T Innovation 2025 Major Special Programme of Ningbo [2018B10040]
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Calcium phosphate based biomaterials have been widely studied in biomedical areas. Herein, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods were separately prepared and used for coating tantalum (Ta) scaffolds with a polymer of polylactide (PLA). We have found that different crystal phases of calcium phosphate coated on Ta scaffolds displayed different effects on the surface morphologies, mineralization and bovine serum albumin (BSA) release. The ACP-PLA and HA-PLA coated on Ta scaffold were more favorable for in vitro mineralization than bare and PLA coated Ta scaffolds, and resulted in a highly hydrophilic surfaces. Meanwhile, the osteoblast-like cells (MG63) showed favorable properties of adhesion and spreading on both ACP-PLA and HA-PLA coated Ta scaffolds. The ACP-PLA and HA-PLA coated Ta scaffolds showed a high biocompatibility and potential applications for in vivo bone defect repair.
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