Journal
RSC ADVANCES
Volume 10, Issue 13, Pages 7855-7866Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra01352h
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Funding
- KRICT, Republic of Korea [SI1935-10]
- National Research Foundation of Korea [NRF2019R1C1C1004970]
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A copper-catalyzed three-component annulation for the synthesis of functionalized 2-quinolones was developed. Three reactions including an S(N)2, a Knoevenagel, and finally C-N bond formation are involved in the designed cascade reaction using 2-bromoacylarenes, 2-iodoacetamide, and nucleophiles as the three components. A new catalytic system was discovered during the study and this modular approach is highly efficient to access functionalized 2-quinolone derivatives, compatible with a broad range of functional groups, scalable, and step-economic. Further derivatization of the obtained product demonstrates the synthetic utility of this method.
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