Related references
Note: Only part of the references are listed.Allosteric Modulation of Nicotinic Acetylcholine Receptors: The Concept and Therapeutic Trends
Victor V. Uteshev
CURRENT PHARMACEUTICAL DESIGN (2016)
X-ray structure of the human α4β2 nicotinic receptor
Claudio L. Morales-Perez et al.
NATURE (2016)
Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator
Ayman K. Hamouda et al.
MOLECULAR PHARMACOLOGY (2016)
A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit
Jingyi Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Nicotinic ACh receptors as therapeutic targets in CNS disorders
Kelly T. Dineley et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Targeting α4β2 Nicotinic Acetylcholine Receptors in Central Nervous System Disorders: Perspectives on Positive Allosteric Modulation as a Therapeutic Approach
Morten Grupe et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)
Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit
Maegan M. Weltzin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor
Ayman K. Hamouda et al.
MOLECULAR PHARMACOLOGY (2015)
Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at α4β2 Nicotinic Acetylcholine Receptors
Jeppe A. Olsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Non-equivalent Ligand Selectivity of Agonist Sites in (α4β2)2α4 Nicotinic Acetylcholine Receptors A KEY DETERMINANT OF AGONIST EFFICACY
Simone Mazzaferro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The Unique α4(+)/(-) a4 Agonist Binding Site in (α4)3(β2)2 Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the α4)2(β2)73 Subtypes
J. Brek Eaton et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
The Nicotinic α5 Subunit Can Replace Either an Acetylcholine-Binding or Nonbinding Subunit in the α4β2☆ Neuronal Nicotinic Receptor
Xiaochun Jin et al.
MOLECULAR PHARMACOLOGY (2014)
Two Distinct Allosteric Binding Sites at α4β2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors
Jeppe A. Olsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Physostigmine and Galanthamine Bind in the Presence of Agonist at the Canonical and Noncanonical Subunit Interfaces of a Nicotinic Acetylcholine Receptor
Ayman K. Hamouda et al.
JOURNAL OF NEUROSCIENCE (2013)
Nicotinic acetylcholine receptors: From basic science to therapeutics
Raymond Hurst et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors
D. B. Timmermann et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Structure and Pharmacology of Pentameric Receptor Channels: From Bacteria to Brain
Pierre-Jean Corringer et al.
STRUCTURE (2012)
Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations
Dustin K. Williams et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Multiple Transmembrane Binding Sites for p-Trifluoromethyldiazirinyl-etomidate, a Photoreactive Torpedo Nicotinic Acetylcholine Receptor Allosteric Inhibitor
Ayman K. Hamouda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Portable Site: A Binding Element for 17β-Estradiol Can Be Placed on Any Subunit of a Nicotinic α4β2 Receptor
Xiaochun Jin et al.
JOURNAL OF NEUROSCIENCE (2011)
Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors
Kasper Harpsoe et al.
JOURNAL OF NEUROSCIENCE (2011)
[3H]Epibatidine Photolabels Non-equivalent Amino Acids in the Agonist Binding Site of Torpedo and α4β2 Nicotinic Acetylcholine Receptors
Shouryadeep Srivastava et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Positive Allosteric Modulator Morantel Binds at Noncanonical Subunit Interfaces of Neuronal Nicotinic Acetylcholine Receptors
Seungmae Seo et al.
JOURNAL OF NEUROSCIENCE (2009)
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Antoine Taly et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators
Brian K. Albrecht et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
Selvanayagam Nirthanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gareth T. Young et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
α4β2 nicotinic receptors with high and low acetylcholine sensitivity:: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
Mirko Moroni et al.
MOLECULAR PHARMACOLOGY (2006)
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Cecilia Gotti et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite
F Sala et al.
NEUROSCIENCE LETTERS (2005)
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures
PHN Celie et al.
NEURON (2004)
Detailed analysis of grid-based molecular docking: A case study of CDOCKER - A CHARMm-based MD docking algorithm
GS Wu et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2003)
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
ME Nelson et al.
MOLECULAR PHARMACOLOGY (2003)
Share Paper
