Journal
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Volume 39, Issue 8, Pages 1495-1502Publisher
SPRINGER
DOI: 10.1007/s10096-020-03856-1
Keywords
Third-generation cephalosporins-resistance; Escherichia coli; Klebsiella pneumoniae; Antibiotic consumption; Extended spectrum beta-lactamase
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Funding
- National Natural Science Foundation of China [81361138021, 81711530049]
- Key Research and Development Program of Zhejiang Province [2015C03032]
- Zhejiang Province Medical Science and Technology Project [2017KY339]
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This study sought to discuss the correlation between the third-generation cephalosporins (3GC)-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption intensity from 143 Chinese tertiary hospitals in 2014. With a retrospective design, the correlation between antibiotic consumption and 3GC-resistant E. coli and K. pneumoniae were performed. 3GC-resistant E. coli was significantly correlated with the consumption of all antibiotics (r = 0.252, p < 0.01), beta-Lactams antibiotics (r = 0.313, p < 0.01), beta-Lactams excluding combinations with beta-lactamase inhibitors (r = 0.365, p < 0.01), cephalosporin (r = 0.398, p < 0.01), cephalosporins excluding combinations with beta-lactamase inhibitors (r = 0.374, p < 0.01), 3GC (r = 0.321, p < 0.01), and 3GC excluding combinations with beta-lactamase inhibitors (r = 0.343, p < 0.01). 3GC-resistant K. pneumoniae was significantly correlated with the consumption of all antibiotics (r = 0.200, p < 0.05), beta-Lactams antibiotics (r = 0.232, p < 0.01), cephalosporin (r = 0.215, p < 0.05), 3GC (r = 0.383, p < 0.01), 3GC excluding combinations with beta-lactamase inhibitors (r = 0.245, p < 0.01), and beta-lactam-beta-lactamase inhibitor combinations (r = 0.218, p < 0.05). There was a significant relationship between the antibiotic consumption and the rates of 3GC-resistant E. coli and K. pneumoniae. Clinicians should grasp the indication of antibiotics use to reduce the production of drug-resistant bacteria.
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