Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 44, Pages 17981-17990Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.802512
Keywords
ABC transporter; gram-negative bacteria; lipopolysaccharide (LPS); outer membrane; protein-protein interaction; LPS transport
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Funding
- Train2Target project from the European Union [721484]
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The outer membrane (OM) of Gram-negative is a unique lipid bilayer containing LPS in its outer leaflet. Because of the presence of amphipathic LPS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria inherently resistant to many antibiotics. This review focuses on LPS biogenesis and discusses recent advances that have contributed to our understanding of how this complex molecule is transported across the cellular envelope and is assembled at the OM outer leaflet. Clearly, this knowledge represents an important platform for the development of novel therapeutic options to manage Gram-negative infections.
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