Related references
Note: Only part of the references are listed.The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process
Deli Huang et al.
MOLECULAR AND CELLULAR BIOLOGY (2017)
MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
Shuzhen Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
Yingying Zhang et al.
NATURE COMMUNICATIONS (2017)
Oxidative Stress
Helmut Sies et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
D. A. Rodriguez et al.
CELL DEATH AND DIFFERENTIATION (2016)
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
Roshan J. Thapa et al.
CELL HOST & MICROBE (2016)
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis
Giovanni Quarato et al.
MOLECULAR CELL (2016)
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Yasushi Ito et al.
SCIENCE (2016)
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
Tania Love Aaes et al.
CELL REPORTS (2016)
Programmed Necrosis in the Cross Talk of Cell Death and Inflammation
Francis Ka-Ming Chan et al.
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)
RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice
Zhe Huang et al.
CELL HOST & MICROBE (2015)
A Role for Tubular Necroptosis in Cisplatin-Induced AKI
Yanfang Xu et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality
Lingjun Meng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Necroptosis: The Trojan horse in cell autonomous antiviral host defense
Edward S. Mocarski et al.
VIROLOGY (2015)
Activation of Necroptosis in Multiple Sclerosis
Dimitry Ofengeim et al.
CELL REPORTS (2015)
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Xin Chen et al.
CELL RESEARCH (2014)
Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
Huayi Wang et al.
MOLECULAR CELL (2014)
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Zhenyu Cai et al.
NATURE CELL BIOLOGY (2014)
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
Diane B. Re et al.
NEURON (2014)
Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
Xing Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M. Hildebrand et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A Plug Release Mechanism for Membrane Permeation by MLKL
Lijing Su et al.
STRUCTURE (2014)
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Yves Dondelinger et al.
CELL REPORTS (2014)
Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation
Ryodai Shindo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
Agnieszka Kaczmarek et al.
IMMUNITY (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Thioredoxin System in Cell Death Progression
Jun Lu et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Liming Sun et al.
CELL (2012)
The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
Zhigao Wang et al.
CELL (2012)
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
L. Galluzzi et al.
CELL DEATH AND DIFFERENTIATION (2012)
DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA
Jason W. Upton et al.
CELL HOST & MICROBE (2012)
A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy
Ramesh K. Ramanathan et al.
INVESTIGATIONAL NEW DRUGS (2012)
Dichotomy between RIP1- and RIP3-Mediated Necroptosis in Tumor Necrosis Factor-α-Induced Shock
Andreas Linkermann et al.
MOLECULAR MEDICINE (2012)
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
Jie Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination
Ramesh K. Ramanathan et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
Linde Duprez et al.
IMMUNITY (2011)
Necroptosis as an alternative form of programmed cell death
Dana E. Christofferson et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
YoungSik Cho et al.
CELL (2009)
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
Sudan He et al.
CELL (2009)
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
Duan-Wu Zhang et al.
SCIENCE (2009)
Identification of RIP1 kinase as a specific cellular target of necrostatins
Alexei Degterev et al.
NATURE CHEMICAL BIOLOGY (2008)
Apoptosis and necrosis: Detection, discrimination and phagocytosis
Dmitri V. Krysko et al.
METHODS (2008)
A small molecule Smac mimic potentiates TRAIL- and TNFα-mediated cell death
L Li et al.
SCIENCE (2004)
Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner
YM Liu et al.
CIRCULATION RESEARCH (2002)
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
N Holler et al.
NATURE IMMUNOLOGY (2000)
Physiological functions of thioredoxin and thioredoxin reductase
ESJ Arnér et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)