Journal
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 82, Issue 1, Pages 131-138Publisher
INDIAN PHARMACEUTICAL ASSOC
DOI: 10.36468/pharmaceutical-sciences.630
Keywords
Amiodarone; chitosan nanoparticles; cyclodextrin; drug release; ionic gelation method
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This work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with beta-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodarone-loaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.
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