Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 42, Pages 17559-17560Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.H117.806901
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Funding
- National Institutes of Health [AG044552, AI121621, DK112365]
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Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1. This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and nonrenal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.
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