Emerging Strategies for C-H Silylation

Silicon-containing molecules are of great academic and industrial interest with widespread applications in several research areas such as materials science, medicinal chemistry, and complex-molecule synthesis. C-Si bond formation by direct C-H functionalization is a modern synthetic approach toward highly valuable compounds that offers a superior step and atom economy in contrast to conventional procedures involving at least one prefunctionalized reaction partner. In this review, we summarize the different strategies for C-H silylation. Organized by their reaction mechanism, a representative selection of recent methodologies is introduced and compared with regard to their substrate scope, functional-group tolerance, and regioselectivity.