Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 31, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/jbt.21937
Keywords
doxorubicin; ellagic acid; rosmarinic acid; sperm; testicular injury
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The anticancer drug doxorubicin causestesticulartoxicityas an undesirable effect. The present study was undertaken to investigate the possible protection of ellagic acid and rosmarinic acid during doxorubicin administration. For this purpose eight groups of male Sprague-Dawley rats were used (n = 10), one group received vehicle served as control, and other groups received 5mg/kg doxorubicin twice a week for 2 weeks for a cumulative dose of 20mg/kg, ellagic acid (10mg/kg/day, 14 consecutive days p.o.), rosmarinic acid (75mg/kg/day, 14 consecutive days p.o.), ellagic acid and rosmarinic acid. The latter three regimens were given to control and doxorubicin-received rats. Doxorubicin decreased testicular relative weight, sperm count, motility, serum testosterone, testicular glycogen, and sialic acid with increased incidence of histopathological changes, oxidative stress, tumor necrosis factor-alpha, as well as cholinesterase activity. Conversely, ellagic and rosmarinic acid treatment ameliorated such damage, thus showing the possibility to use as an adjuvant during doxorubicin treatment.
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