Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 31, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/jbt.21916
Keywords
chromium (VI); histopathological studies; liver damage; oxidative stress; selenium
Categories
Funding
- National Key RD Program [2016YFD0501208]
- Shandong Modern Agricultural Technology & Industry System [SDAIT-11-04]
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This study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]-induced damage in chicken liver. A total of 105 chickens were randomly divided into seven groups of 15. Group I received deionized water; group II received Cr(VI) (7.83mg/kg/d) alone; and other groups orally received both Cr(VI) (7.83mg/kg/d) and Se of different doses (0.14, 0.29, 0.57, 1.14, and 2.28mg/kg/d). The levels of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca2+-ATPase, and mitochondrial membrane potential (MMP) were measured. Results showed that Cr(VI) increased MDA content and decreased GSH content, T-SOD activity, Ca2+-ATPase activity, and MMP level. Meanwhile, Se co-treatment (0.14, 0.29, and 0.57mg/kg/d) increased the viability of the above indicators compared with Cr(VI)-treatment alone. In addition, histopathologic examination revealed that Cr(VI) can cause liver damage, whereas Se supplementation of moderate dose inhibited this damage. This study confirmed that Se exerted protective effect against Cr(VI)-induced liver damage.
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