Journal
NANOSCALE ADVANCES
Volume 2, Issue 3, Pages 1138-1143Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9na00644c
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Funding
- National Key Research and Development Program of China [2017YFA0205301]
- NSF of China [61527806, 61871180, 61901168, 61971187, 81902153, 81430055]
- Programs for Changjiang Scholars and Innovative Research Team in University [IRT_15R13]
- State Key Laboratory of Oral Diseases [SKLOD2019OF03]
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Accurate detection of markers in human serum is important in the early diagnosis of acute myocardial infarction (AMI). This work presents a novel eight biomarker strip, which combines dry chemistry with a fluorescence lateral flow assay. Eight AMI markers were employed simultaneously for sensitive detection, including cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), uric acid (UA), myoglobin (Myo), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI). The strip offers the advantages of simple fabrication, convenience, time-saving detection and accurate assessment for AMI. Moreover, the strip possesses acceptable applicability for human serum. This proposed strategy establishes a remarkable platform for the construction of a multi-target detection strip that is feasible for accurate detection for real human serum samples.
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