Journal
TRENDS IN CHEMISTRY
Volume 2, Issue 3, Pages 183-198Publisher
CELL PRESS
DOI: 10.1016/j.trechm.2019.12.002
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Funding
- NIGMS [2R01GM109054]
- University of Chicago
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C-C bond activation has emerged as an increasingly useful approach for constructing complex molecular scaffolds through unusual bond-disconnection strategies. As a common versatile functional group, ketones provide an excellent handle and platform for C-C bond activation reactions. Utilizing strain-release, carbon-monoxide-extrusion, and directing-group (DG) approaches, diverse transformations of various ketones have been developed in the past few decades through cleavage of their a C-C bonds. This review highlights the development of C-C bond-activation strategies for both strained and less strained ketones with a focus on transition-metal (TM)-catalyzed approaches.
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