Journal
CLINICAL AND TRANSLATIONAL MEDICINE
Volume 10, Issue 1, Pages 116-124Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ctm2.15
Keywords
cancer; gene sequencing; MDTS-PM; precision medicine; target therapy
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Funding
- National Natural Science Foundation of China [81870098]
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The application of precision medicine concept in clinical work needs a period of practice and experience accumulation. The present article introduced an example of functioning approach named multidisciplinary therapy strategy of precision medicine (MDTS-PM), clinical practice and process, decision-making, and therapies. The MDTS-PM integrates multidisciplinary experts and develops real-time therapeutic strategy based on clinical phenomes and gene sequencing of tissue DNA and circulating DNA. The strength of MDTS-PM is the combination of dynamical clinical phenomes, genetic information, diagnosis, and treatment to make the therapy more targeted and specific. MDTS-PM provides comprehensive, whole-process, and personalized diagnosis and treatment services for patients with complex cancer or complex drug resistance progression; provides guidance for further adjustment of drug use; and establishes a multidisciplinary cooperative team, improves the quality of clinical diagnosis and treatment, and optimizes the process of medical services.
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