Journal
RSC ADVANCES
Volume 10, Issue 17, Pages 10197-10220Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra00894j
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Funding
- National Natural Science Foundation of China [21772210, 81973235, 21977102]
- Special Fund for Bagui Scholars of Guangxi
- Scientific Research Foundation of Institute of Marine Drugs, Guangxi University of Chinese Medicine [2018ZD005-A01, 2018ZD005-A17]
- Initial Scientific Research Foundation of Introduced Doctors in 2019 of Guangxi University of Chinese Medicine [2019BS021]
- Guangdong Basic and Applied Basic Research Foundation [2019B151502042, 2018A0303130219]
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Azaphilones have continuously aroused considerable attention owing to their structural diversity and significant biological activities recently. This review attempts to give a comprehensive summary of recent progress on the isolation, identification, and biological activity, along with synthetic and biosynthetic studies of azaphilones reported from October 2012 to December 2019. Herein, a total of 252 compounds predominantly originated from 32 genera of fungi, such as Penicillium (20%) and Talaromyces (11%), were included in this research with citations of 105 references. Among these azaphilones, approximately half of them were found with various biological activities, of which over 40% displayed cytotoxic/anti-tumor effects. This review would shed light on the future development and research of azaphilones.
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