Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 20, Issue 6, Pages 559-569Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1327949
Keywords
Apoptosis; H522 cells; extrinsic pathway; lung cancer; hesperetin
Funding
- Deanship of Scientific Research, King Saud University, Saudi Arabia Research Group [RG-1435-044]
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We studied the chemoprevention property of hesperetin on H522 cells using MTT, an apoptosis assay, an analysis of cell cycle progression, and the mitochondrial membrane potential, and apoptotic marker gene expression was determined using quantitative PCR. Hesperetin enhanced apoptotic cell death and mitochondrial membrane potential loss in H522 cells. Hesperetin up-regulated the levels of Fas, FADD, and caspase-8 expression and downregulted the levels of caspase-3 and caspase-9, p53, and Bax expression in H522 cells. This study shows that hesperetin induces apoptosis in H522 cells via a pathway independentof p53 and Bax but triggers the death-receptor Fas-initiated FADD/ caspase-8-dependent apoptotic pathway. [GRAPHICS] .
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