Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 20, Issue 10, Pages 920-927Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1373100
Keywords
Croton kongensis; 8; 9-seco-ent-kaurane; diterpenoids; cytotoxicity
Funding
- National Natural Science Foundation of China [U1302222]
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Chemical study on the ethanolic extract generated from the aerial parts of Croton kongensis led to the isolation of three new 8,9-seco-ent-kaurane diterpenoids, kongeniods AC (13), together with seven known analogs (4-10). The structures of these compounds were assigned by spectroscopic data analysis. The vitro cytotoxic tests showed that compounds 1-3 exhibited strong activities against HL-60 cell lines with IC50 values of 0.47, 0.58, and 1.27M, respectively. [GRAPHICS] .
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