Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 19, Issue 10, Pages 1028-1035Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1285908
Keywords
Steroids; sorbicillinoids; Trichoderma sp.; Xy24; anti-HIV activity; anti-inflammatory activity; cytotoxicity
Funding
- CAMS Innovation Fund for Medical Sciences [CIFMS-2016-I2M-3-012]
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A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 mu M; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 mu M, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 mu M, respectively.
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