Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 19, Issue 12, Pages 1214-1231Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1317751
Keywords
Chemotherapy drug; lung; stomach; oleuropein; histology; oxidative DNA damage
Funding
- Ataturk University [BAP-2015/94]
Ask authors/readers for more resources
The current systemic treatments of the various solid tumors involve Cisplatin (CIS)-based chemotherapy. Due to its cytotoxicity, this approach is limited. Moreover, the safety of CIS is only discussed especially in breast and stomach cancers. Therefore, we, for the first time, explored the restorative efficacy of oleuropein (OLE), in stomach and lung injuries induced by CIS. Sprague-Dawley rats were divided into eight groups: control CIS, OLE and CIS+OLE. Single dose of (7mg/kg) CIS was administered intraperitoneally to CIS and CIS+OLE groups. After 24h, 50, 100 and 200mg/kg OLE was given for three consecutive days to OLE and CIS+OLE groups. The 8-OH-dG, total oxidative/antioxidant status (TOS/TAS) and malondialdehyde (MDA) levels were evaluated and histopathological analyses were performed on the studied tissues. The results indicated that CIS significantly increased 8-OH-dG, MDA and TOS levels and caused severe tissue damages. However, high dose of OLE induced a significant decrease in the 8-OH-dG, MDA levels, an increase in TAS levels and it restores CIS-induced tissue damages. We hope that the results of this study will provide an impetus for future studies on novel therapeutic strategies including the protective use of oleuropein in gastric and lung cancers due to chemotherapy. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available