Journal
NANOSCALE
Volume 12, Issue 11, Pages 6489-6497Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr00638f
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Funding
- National Natural Science Foundation of China [21575138, 21775108]
- Construction of Platform for State Key Laboratory of Food Nutrition and Safety [18PTSYJC00130]
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A multifunctional plasmonic gold chip has been constructed for early diagnosis and highly effective killing of bacteria, which is critical for human health. The chip features high bacterial capture efficiency, plasmon-enhanced fluorescence (PEF) and surface-enhanced Raman scattering (SERS) and can act as a highly sensitive sensor for dual-mode bacteria imaging and detection (down to 10(2) CFU mL(-1)) with good reliability and accuracy. The developed assay can distinguish Gram-positive S. aureus bacteria from Gram-negative E. coli bacteria, providing valuable information for therapy. Importantly, the chip presents excellent photothermal antibacterial activity (98%) and can inactivate both Gram-positive and Gram-negative bacteria in situ. Furthermore, the chip was used to effectively promote the wound healing process in bacteria infected mice in vivo, showing great potential for antibacterial applications.
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