Journal
EURASIAN CHEMICAL COMMUNICATIONS
Volume 2, Issue 6, Pages 702-711Publisher
SAMI PUBLISHING CO-SPC
DOI: 10.33945/SAMI/ECC.2020.6.7
Keywords
Isoprenaline; NiO-based composite; nanostructure sensor; modified carbon paste electrode; drug sensor
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Funding
- Mashhad Branch, Islamic Azad University
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A high sensitive electroanalytical-based sensor for determination of isoprenaline was fabricated by modification of carbon paste electrode (CPE) by NiO-Pt-Pd/CNTs composite as conductive mediator and n-hexyl-3-methylimidazolium hexafluoro phosphate (NHIHP) as conductive binder. The NHIHP/NiO-Pt-Pd/CNTs/CPE was improved the oxidation signal of isoprenaline square 3.47 times and reduced oxidation over- potential of drug square 180 mV. The pH investigation confirmed that redox behavior of isoprenaline is depended of pH solution with equal value of electron and proton in redox mechanism. The NHIHP/NiO-Pt-Pd/CNTs/CPE was successfully used for determination of isoprenaline in the concertation range 0.003-300 mu M with detection limit 0.9 nM by square wave voltammetric method. The standard addition results showed powerful ability of NHIHP/NiO-Pt-Pd/CNTs/CPE as an electroanalytical tool for determination of isoprenaline in the pharmaceutical and clinical samples with recovery data 98.76-105.06%.
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