Journal
RADIATION ONCOLOGY JOURNAL
Volume 38, Issue 1, Pages 52-59Publisher
KOREAN SOC THERAPEUTIC RADIOLOGY & ONCOLOGY
DOI: 10.3857/roj.2020.00101
Keywords
Prostatic neoplasms; Magnetic resonance imaging; Helical tomotherapy
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2018R1C1B6006273]
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Purpose: To evaluate and compare the feasibilities of magnetic resonance (MR) image-based planning using synthetic computed tomography (sCT) versus CT (pCT)-based planning in helical tomotherapy for prostate cancer. Materials and Methods: A retrospective evaluation was performed in 16 patients with prostate cancer who had been treated with helical tomotherapy. MR images were acquired using a dedicated therapy sequence; sCT images were generated using magnetic resonance for calculating attenuation (MRCAT). The three-dimensional dose distribution according to sCT was recalculated using a previously optimized plan and was compared with the doses calculated using pCT. Results: The mean planning target volume doses calculated by sCT and pCT differed by 0.65% +/- 1.11% (p = 0.03). Three-dimensional gamma analysis at a 2%/2 mm dose difference/distance to agreement yielded a pass rate of 0.976 (range, 0.658 to 0.986). Conclusion: The dose distribution results obtained using tomotherapy from MR-only simulations were in good agreement with the dose distribution results from simulation CT, with mean dose differences of less than 1% for target volume and normal organs in patients with prostate cancer.
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