Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 38, Issue 1, Pages 3-24Publisher
WILEY
DOI: 10.1002/jat.3476
Keywords
nanoparticles (NPs); nanomaterials; physical and chemical properties; potential applications; nanomedicine products; clinical trials; human biosafety
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Funding
- National Nature Science Foundation of China [81273111]
- Scientific Projects of Zhejiang Province [2015C33148, 2015C37117]
- Ningbo Scientific Innovation Team for Environmental Hazardous Factor Control and Prevention [2016C51001]
- KC Wong Magna Fund in Ningbo University
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With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern. If nanoparticles accumulate in the human body or interact with the body molecules or chemical components, health risks may also occur. Accordingly, the unique chemical and physical properties, potential applications in medical fields, as well as human biosafety in clinical trials are reviewed in this study. Finally, this article tries to give some suggestions for future work in nanomedicine research. Copyright (c) 2017 John Wiley & Sons, Ltd.
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