4.7 Article

An interpenetrated bioactive nonlinear optical MOF containing a coordinated quinolone-like drug and Zn(II) for pH-responsive release

Journal

DALTON TRANSACTIONS
Volume 44, Issue 4, Pages 1800-1804

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt02672a

Keywords

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Funding

  1. 973 Program [2012CB821701, IRT1156]
  2. NSFC [20925101, 21101102]
  3. Shanxi Province Science Foundation for Youths [2012021008-2]

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A new interpenetrated bioactive nonlinear optical metal-organic framework [Zn-2(ppa)(2)(1,3-bdc)(H2O)] has been designed and synthesized, which shows both a high drug content of 63.9% and a good slow release effect in simulated physical conditions compared to other non-interpenetrated bioactive MOFs. It also shows a large powder second-harmonic generation (SHG) efficiency of 5.6 times that of KH2PO4 (particle size: 150-200 mu m).

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