Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 7, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2020.1735912
Keywords
Antimitotic; BH3 mimetics; inflammatory secretome; apoptotic priming
Categories
Funding
- Ligue contre le Cancer Grand-Ouest
- Canceropole Grand-Ouest
- Region Pays de la Loire
- Agence Nationale de la Recherche
- SIRIC ILIAD program
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We recently identified a previously unappreciated ability of antimitotics to propagate apoptotic priming across cancer cell populations. The underlying paracrine cytotoxic signal, fueled by undead cells activating the cGAS/STING pathway, is required for in vivo antitumor response and it can be further exploited by delayed, but not synchronous, BCL-xL inhibition.
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