Journal
DALTON TRANSACTIONS
Volume 44, Issue 14, Pages 6613-6619Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5dt00012b
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Funding
- National Natural Science Foundation of China [21102002, 21372005, 21272223]
- 211 Project of Anhui University
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A novel two-photon fluorescent probe (HQ) for hypochlorite (ClO-) has been developed based on specific ClO- -promoted oxidation of a C=N bond. The probe shows linear fluorescence responses to ClO- with 23.5-fold enhancement. Two-photon fluorescence detection signals of HQ to ClO- were observed with high selectivity and sensitivity. The good biocompatibility guaranteed the use of HQ to detect intracellular ClO- under two-photon excitation. Moreover, HQ has been successfully applied to monitor the endogenously produced hypochlorite in living cells (BV-2) stimulated by lipopolysaccharide (LPS). HQ provides a new ClO- detection agent for the discovery of pharmacological microglia modulators by high-throughput screening.
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